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A cDNA library of human osteoblast-like cells was constructed and screened with D-alpha-hydroxyacid dehydrogenase (DHAD) cDNA clones. One positive clone was isolated and sequenced. The corresponding gene, herein named DHAD4, consists of two exons separated by a large intron. The sequence contains an amino-terminal putative transmembrane domain and a carboxyl-terminal domain with consensus sequence of active site and regulatory elements. DHAD4 mRNA was detected in all human tissues by Northern blot analysis and was upregulated by cyclic mechanical strain in C2C12 mouse muscle cells. The regulation by cyclic strain and the tissue distribution of DHAD4 mRNA are different from those of previously reported DHAD genes.Anthropologists from the University of Bristol and the University of Salford have been tracing the role of foot size in human evolution, specifically to shed light on the development of human bipedalism.
Using population genetic and fossil evidence, the researchers looked at the distribution of modern human bipedalism in Africa and its relation to the smaller feet of pre-bipedal apes, such as chimpanzees and gorillas.
This study, published today (30 August) in the journal Nature, showed that natural selection and genetic drift have shaped the human foot by reducing the size of modern foot and ankle bones.
It also explains the evolutionary role of the human foot: humans began by walking on two legs like chimpanzees, but then 0b46394aab